- PRGF - ENDORET®
- Medical specialties
- BTI APNIA®
- Diagnosis
- Treatment

Bimaxillary splint connected by means of traction adjusters that prevent retrusion and/or allow mandibular advancement. This helps maintain airway patency during sleep, achieving a steady, uninterrupted oxygen flow and thereby reducing the number of apnoeic episodes and snoring events.

Treatment of obstructive sleep apnoea and snoring
It is particularly recommended for individuals with sleep apnoea or chronic snoring, and is an ideal alternative for patients who have not achieved symptom relief through lifestyle changes or who are intolerant to treatment with positive airway pressure devices (CPAP).
The APNIA Intraoral Device (DIA) stands out for its optimal fit and retention, ensuring maximum patient comfort, thanks to a design with minimal vertical dimension and submillimetre thicknesses that reduce the impact on the temporomandibular joint (TMJ). Its intelligent design, supported by an Artificial Intelligence (AI) algorithm that analyses each patient’s requirements, ensures millimetric precision.
In addition, it stands out for its durability, as it is manufactured from a highly resilient material capable of withstanding daily mechanical loading and fatigue associated with prolonged use (certified under ISO 10993), while providing triaxial freedom of movement that reduces friction and absorbs impacts.
As an added benefit to help prevent changes in occlusion, the treatment includes a stabilisation splint, which the patient wears for 5–10 minutes after waking to help the condyle reposition the mandible rapidly into centric relation.
The manufacturing process is based on proprietary digital design and manufacturing technology carried out at the HTL CAD/CAM-Lab production centre, which provides a 2-year quality guarantee. The workflow begins with acquisition of the models in .STL or .PLY format, either through direct intraoral scanning or by means of a desktop scanner, after which they are processed using exclusive software that acts as a functional virtual articulator adapted to the patient’s biomechanics. Occlusal design and adjustment are micrometric, employing an insertion vector that simulates the exact seating of the splint in the mouth and avoids the need for subsequent adjustments.
Finally, all splints are produced using sophisticated additive manufacturing technology, with a material of controlled porosity and responsiveness to thermal stimuli, which increases its flexibility and comfort once body temperature is reached.
DIA intraoral device
Advanced digital technology for optimal sleep, reducing apnoeic episodes with maximum comfort.

System incorporating 7 interchangeable components of different lengths. This technology enables millimetric customisation of the degree of mandibular advancement for each patient, ensuring progressive adaptation and considerable versatility throughout treatment.

Articulation mechanism based on a high-strength reinforced wire. This solution stabilises the mandible effectively to prevent retrusion during sleep, ensuring correct airway opening in a comfortable and safe manner.

The DIA is designed to be comfortable and easy to use. It does not require complicated adjustments; it is simply fitted in the mouth before sleep.
Each device is custom-made, ensuring a perfect fit for each patient, thereby improving treatment efficacy and user comfort.
Clinical studies have shown that the DIA is highly effective in reducing apnoea episodes and significantly improving quality of sleep.
As an intraoral device, the DIA is discreet and easy to wear overnight, without the need for a noisy or cumbersome machine.
Ideal for patients who travel frequently, as it does not require bulky equipment or an electrical power supply.
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BTI Update
The interdisciplinary workflow for the manufacture of the DIA begins in consultations with pulmonologists, sleep unit specialists or ear, nose and throat specialists (ENT), who, after diagnosing sleep apnoea or chronic snoring, refer the patient to the dentist if they consider them an appropriate candidate or if they show intolerance to CPAP. At the dental clinic, the dentist performs an intraoral scan to obtain precise digital models and sends them directly to the HTL CAD/CAM-Lab production centre. There, using exclusive software, the splint is designed and manufactured according to the patient’s biomechanical requirements and is then returned to the clinic for fitting.
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