The use of PRGF – ENDORET® for endometrial conditioning or for the treatment of low ovarian reserve can open up new avenues for fertility recovery.
Endometrial conditioning with plasma rich in growth factors PRGF - ENDORET® promotes embryo implantation.
PRGF – ENDORET® increases endometrial thickness in refractory endometrium treatments. Additionally, it improves the biological environment of the endometrium making it more receptive to embryo implantation.
PRGF – ENDORET® stimulates the proliferation and migration of human endometrial fibroblasts, and the paracrine secretion of biomolecules essential for the improvement of endometrial tissue.
The Platelet-Derived Growth Factor PDGF promotes the repair of endometrial tissue through the stimulation of proliferation, chemotaxis, and invasion of endometrial stromal cells.
The Transforming Growth Factor B (TGF-b1) present in the PRGF can protect the endometrium from extensive fibrosis.
The significant increase in the secretion of Vascular Endothelial Growth Factor VEGF contributes to neovascularization, a key process in the repair and proliferation of the endometrium and in successful embryo implantation.
The treatment of human endometrial fibroblasts with PRGF – ENDORET® significantly improves:
The contractile activity of human endometrial fibroblasts may prevent excessive fibroplasia and promote adequate endometrial regeneration.
The synthesis of type I procollagen and hyaluronic acid, allowing for the renewal and remodeling of the extracellular matrix for a satisfactory restoration of the tissue.
